Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans
Duraimani, Shanthi; Schneider, Robert H.; Randall, Otelio S.; Nidich, Sanford I.; Xu, Shichen; Ketete, Muluemebet; Rainforth, Maxwell A.; Gaylord-King, Carolyn; Salerno, John W.; Fagan, John (2015). Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans. PLOS ONE, 10(11), e0142689.
Sixteen-week volunteer substudy of 48 participants from a randomized trial comparing TM plus basic health education with extensive health education in African Americans with hypertension. No significant between-group advantage was found for telomerase gene expression or systolic blood pressure.
- Year
- 2015
- Journal
- PLOS ONE
- Publication type
- Journal
- Paper type
- Empirical
- Section
- Health
Findings (3)
Biochemical
Telomerase gene-expression changes did not differ significantly between groups; the TM-group hTERT change did not reach conventional significance (p = .055).
Transcendental Meditation · Randomized controlled trial
Health—Cardiovascular
Systolic blood pressure fell within the TM group, but the between-group difference was not significant; diastolic blood pressure favored extensive health education (p = .04).
Transcendental Meditation · Randomized controlled trial
Health Promoting Behavior
Both stress reduction and health education were evaluated as lifestyle approaches; the small volunteer substudy does not establish telomere lengthening.
Transcendental Meditation · Randomized controlled trial